Orphan of mother at the five years age, Colomb is raised by his/her maternal grandmother. She passes her childhood and her youth to Begnins then to Lausanne, where she completes into 1916 of the traditional studies by an arts degree. She writes a doctorate on “Happy of Muralt, traveller and fanatic” whom she gives up before defense. Except for long stays in Germany, in England and Paris before its marriage and the birth of his/her two sons (1923 and 1929), Colomb will live, for all its life, in the Country of Vaud, in Yverdon, Lausanne and Prilly.

From 1921, it starts to write in secrecy. It publishes a first novel, Pile or Face (1934), under the pseudonym of Catherine Tissot. About ten years the publication separates from each one of its books: Castles in childhood (1945), Spirits of the ground (1953) and the Time of the angels (1962), which it signs Catherine Colomb (all three translated today into German). She works until her death with a last novel, the Kingdoms combatants, remained unfinished.

Although it was member of the Association of the writers of Vaud, of the Company of the Swiss writers, the Swiss Association of the university women, Colomb was held remotely of the literary currents of its time. The trilogy, misunderstood at the time by the traditional French critic, was noticed by the poet Gustave Roud and, in France, by Jean Paulhan in particular, before being recognized in French Switzerland like one of the most important novels of second half of the century. Colomb was distinguished by the jury from the Price from the Guild from the Book (1945) and received the Price of the Book of Vaud (1956) and the Price Rambert (1962).